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Home > Articles > Press Releases > The Pig as an Animal Model for Health Research

 

The Pig as an Animal Model for Health Research

Posted in: Press Releases by admin on April 27, 2011


Two interactive discussions were held on October 19, 2010 at the University of Saskatchewan in order to bring health researchers together to discuss opportunities for using pigs in research projects.  For more information click here!

For information on The Pig as a Model, New Initiatives Grant Awards click here!

The application date to apply for Award #1 has passed

To apply for Award #2 click here!


Remember when submitting the application for awards convert document to PDF and submit to katie.carr@usask.ca prior to 16:30 on the deadline day.

  

The following is a list of references for articles (review, original research) relating to the use of the pig as an animal model.

This is not intended to be an exhaustive list but will provide some examples of research areas utilizing the pig as an animal model. The listed areas include: general information, obesity/metabolic syndrome/diabetes, cardiovascular, pharmacology/toxicology, neuroscience, skin/wound healing and dental.

Feel free to recommend other useful articles to katie.carr@usask.ca.

General : swine in biomedical research

  1. Schook L, et al. 2005 Swine in biomedical research: creating the building blocks of animal models. Anim Biotch 16:183-90.
  2. Lunney JK. 2007. Advances in swine biomedical model genomics. Int J Biol Sci. 3:178-84.
  3. Humphrey SJ, et al. 2007. A highly integrated map of the pig genome. Genome Biol. 8:R139.1-R139.11
  4. Swindle MM, Smith AC. 2007. Swine in biomedical research. In Conn PM, ed. Sourcebook of Models for Biomedical Research. Humana Press Inc, Totowa, NJ. Pp: 233-9.
  5. Vodička P, et al. 2005. The miniature pig as an animal model in biomedical research. Ann New York Acad Sci. 1049:161-71

Obesity/metabolic syndrome/diabetes

  1. Arner P. 2005. Resistin: yet another adipokine tells us that men are not mice. Diabetologica. 48:2203-5.
  2. Spurlock ME, Gabler NK. 2008. The development of porcine models of obesity and the metabolic syndrome. J Nutr. 138:397-402.
  3. Litten-Brown JC, et al. 2010. Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview. Animal. 4:899-920.
  4. Brambilla G, Cantafora A. 2004. Metabolic and cardiovascular disorders in highly inbred lines for intensive pig farming: how animal welfare evaluation could improve the basic knowledge of human obesity. Ann 1st Super Sanitá. 40:241-4.
  5. Sébert SP, et al. 2005. Childhood obesity and insulin resistance in a Yucatan minipiglet model: putative  roles of IGF-1 and muscle PPARs in adipose tissue activity and development. Int J Obes. 29:324-33.
  6. Kim K-S, et al. 2004. Investigation of obesity candidate genes on porcine fat deposition quantitative trait loci regions. Obes Res. 12:1981-94.

Cardiovascular

  1. Bloor CM, et al. 1992. The pig as a model of mycardial ischemia and gradual coronary occlusion. In: Swindle MM, Ed. Swine as models in biomedical research. Ames, IA. Iowa State Univ Press. Pp 163-75.
  2. Gootman PM. 2001. Cardiovascular system: In: Pond WG, et al. Eds. Biology of the domestic pig. Ithaca, NY. Cornell Univ Press. Pp 553-9.
  3. Reffelmann T, et al. 2004. A novel minimal-invasive model of chronic myocardial infarction in swine. Coron Artery Dis 15:7-12.
  4. Leor J, et al. 2009. Intracoronary injection of in situ forming alginate hydrogel reverses left centricular remodeling after myocardial infarction in swine. J Amer Coll Cardiol. 54:1014-23.
  5. Spuentrup E, et al. 2009. Molecular magnetic resonance imaging of myocardial perfousion with EP-3600 a collagen-specific contrast agent: initial feasibility study in a swine model. Circul. 119:1768-75.

 Pharmacology/toxicology

  1. The RETHINK project: an assessment of the potential impact of toxicity testing in the minpig as an alternative approach in regulatory toxicity testing. Special Issue. J Pharmacol Toxicol Methods. 2010. 62(3):158-242.
  2. a. Webster J, et al. Ethical implications of using the minipig in regulatory toxicology studies 62:160-6.
  3. b. Ellegaard L et al. Welfare of the minipig with special reference to use in regulatory toxicology studies 62:167-83.
  4. c. Van der Laan JW, et al. Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products. 62: 184-95.
  5. d. Bode G, et al. The utility of the minipig as an animal model in regulatory toxicology. 62:196-220.
  6. e. Forster R, et al. The minipig as a platform for new technologies in toxicology 62:227-35.
  7. Svendsen O. 2006. The minipig in toxicology. Exper Toxic Path. 57:335-9.
  8. Rainsford KD, et al. 2003. Gastroinestinal mucosal injury following repeated daily oral administration of conventional formulations of indometacin and other non-steroidal anti-inflammatory drugs to pigs: a model for human gastrointestinal disease. J Pharm Pharmacol. 55:661-8.

Neuroscience

  1. Kornum BR, Kndsen GM. 2010. Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research. Neurosci Behav Rev.  doi:10.1016/j.neubiorev.2010.05.004
  2. Lind NM, et al. 2007. The use of pigs in neuroscience: modeling brain disorders. Neurosci Behav Rev. 31: 728-51.

 Bone disorders

  1. Pearce AI, et al. 2007. Animal models for implant biomaterial research in bone: a review. Europ Cell Mater. 13:1-10.
  2. Brandt KD. 2002. Animal model of osteoarthritis. Biorheology. 39:221-35.
  3. Little CB, Smith MM. 2008. Animal models of osteoarthritis. Curr Rheumat Rev. 4:175-82.
  4. Turner AS. 2001. Animal models of osteoporosis – necessity and limitations. Europ Cell Mater. 1:66-81.

 Skin/wound healing

  1. Wang JF, et al. 2000. Molecular and cell biology of skin wound healing in a pig model. Connect Tiss Res. 41:192-211.
  2. Sullivan TP, et al. 2001. The pig as a model for human wound healing. Wound Rep. Regen.9:66-77.
  3. Godin B, Touitou E. 2007. Transdermal skin delivery: predictions for humans from in vivo, ex vivo, and animal models. Adv Drug Del Rev. 11:1152-61.  
  4. Cuttle L, et al. 2006. A porcine deep dermal partial thickness burn model with hypertrophic scarring. Burns. 32:806-20.
  5. Jacobi U, et al. 2007. Porcine ear skin: an in vitro model for human skin. Skin Res Tech. 13:19-24.
  6. Velander P, et al. 2008. Impaired wound healing in an acute diabetic pig model and the effects of local hyperglycemia. Wound Rep Regen. 16:288-293.

 Dental

  1. Wang S, et al. 2007. The miniature pig: a useful model for dental and orofacial research. Oral Dis. 13:530-7.
  2. Rimondini L, et al. 2005. Tissue healing in implants immediately placed in postextraction sockets: a pilot study in a mini-pig model. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 100:E43-50.

 

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