Gastric ulcers in pigs increase significantly when stressful events occur. However, the exact causes of these gastric ulcerations remain unclear. Gastric acid production is known to be influenced by anionic secretion. An Ussing chamber study was conducted to evaluate the agonist-induced electrogenic secretory responses in the different sections of the stomach of pigs exposed to gastric ulcers. Changes in short-circuit current (Isc) in pigs euthanized 48h after an out-of-feed event significantly decreased following the activation of secretion via the adrenergic agonist in the cardia, and the cholinergic agonist in the pars and pylorus. There were no significant secretory responses in the other segments. Since bumetanide failed to inhibit the basolateral cotransporter 1 (NKCC1), the changes in the stimulatory Isc could be attributed to bicarbonate secretion.
Transepithelial ion transport in the stomach of pigs exposed to gastric ulcer conditions (link to the full article)
